bripharmchem00113-0031

bripharmchem00113-0031

الكاتب: Multiple References

It is generally recognized that the therapy of human trypanosomiasis is at least sufficiently good for the disease to be kept under control, and so the problem of immediate importance in Africa is the control of cattle trypanosomiasis. As much as four and a half million square miles of tropical Africa are considered to be held back from full development mainly by reason of cattle trypanosomiasis, of which the form most widespread, and usually most deadly, is that caused by Trypanosoma congolense. Our early work on the chemotherapy of trypanosomiasis was largely influenced, therefore, by the desire to find a drug for use against T. congolense, although we did not neglect to look for activity also against other species such as T. evansi, T. equinum, and T. equiperdum which occur in Africa and elsewhere. So it happened that while early German work on the chemotherapy of T. congolense gave us a start in our researches, it was some work of ours with T. evansi which led us to " Antrycide." A preliminary account of the discovery was given in Nature (Curd and Davey, 1949).


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