الكاتب: Multiple References

Sulbactam-ampicillin combines ampicillin, a broad spectrum beta-lactam antibiotic, with sulbactam, an irreversible beta-lactamase inhibitor . The sulbactam component prevents the degradation of ampicillin by several major classes of bacterial beta-lactamases and restores the activity of ampicillin against most strains of bacteria in which resistance is mediated by beta-lactamase production . A crossover study was conducted in Friesian calves of 98-119 kg bodyweight in which the plasma kinetics of sulbactam-ampicillin adminstered by the intramuscular and subcutaneous routes were defined, and the plasma kinetics of ampicillin derived from sulbactam-ampicillin and a commercially available formulation of ampicillin trihydrate were compared . Subsequent to both intramuscular and subcutaneous administration of sulbactam-ampicillin, peak plasma concentrations of sulbactam and ampicillin were recorded two hours post-injection . Higher peak plasma concentrations of both sulbactam and ampicillin were achieved by the subcutaneous route of administration and, for ampicillin, the difference between the two routes was statistically significant (p