الكاتب: Multiple References

M. ELGHAZALI* I. A. WASFI* N. A. AL KATHEERI* A. A. A. HADI* & M. M. HUSSEIN *Camelracing Laboratory, Forensic Science Laboratory, PO Box 253, Abu Dhabi, United Arab Emirates; Camel Research Center, Sweihan Road, PO Box 72437, Abu Dhabi, United Arab Emirate Elghazali, M., Was , I. A., Al Katheeri, N. A., Hadi, A. A. A., Hussein, M. M. The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration. J. vet. Pharmacol. Therap. 25, 43±48. The pharmacokinetics of etamiphylline were determined after an intramuscular (i.m.) dose of 3.5 mg/kg body weight in six healthy camels. Furthermore, the metabolites and drug detection time were evaluated. The data obtained median and (range) were as follows: the terminal elimination half-life (t1/2b, h) was 3.04 (2.03±3.62); apparent total body clearance (Cl/F, L/h/kg) was 1.27 (0.74±2.99); the apparent volume of distribution at steady state (Vss/F, L/kg) was 4.94 (3.57±12.54); and renal clearance (Clr, L/h/kg) determined in two camels was 0.005 and 0.004, respectively. The detection time of etamiphylline in urine after an i.m. dose of 3.5 mg/kg body weight ranged between 12 and 13 days. Three etamiphylline metabolites were tentatively identi ed in camels urine: The rst one desethyletamiphylline was the main metabolite and resulted from N-deethylation of etamiphylline had a molecular weight of 251, and was detected in urine for about 13±14 days. Theophylline (molecular weight 180) was the second metabolite and resulted from ring N-dealkylation of etamiphylline. It was present in small amounts and was detected for about 5 h after drug administration in urine. The third metabolite, possibly resulted from demethylation of etamiphylline, had a molecular weight of m/z 265, and was present in small amounts and was detected in urine for about 5 h after drug administration. (Paper received