الكاتب: Multiple References

Anti-inflammatory—Tepoxalin is believed to act through the inhibition of cyclooxygenase activity and also the inhibition of lipoxygenase, making it a dual inhibitor of arachidonic acid metabolism. {R-1} An ex vivo whole blood eicosanoid production assay following oral administration to dogs demonstrated the inhibition of prostaglandin F2alpha and leukotriene B4 by tepoxalin.{R-6} Other effects—Studies in laboratory animals have demonstrated less gastrointestinal ulcerogenic activity with tepoxalin administration than with some nonsteroidal anti-inflammatories, including diclofenac, indomethacin, or naproxen. The mechanism of action of this benefit is uncertain, although tissue-selective prostaglandin inhibition or a protective effect caused by 5-lipoxygenase inhibition have been suggested.