الكاتب: Multiple References

If the transfer of ova is to become practical, simplenon-surgical techniques must be employed. One of the greatest obstacles encountered in nonsurgical techniques for obtaining ova is the difficulty of dilating the cervix at the appropriate time to allow the use ef instruments in the uterus. To facilitate entrance into the uterus, some mechanical or hormonal means of dilating the cervix is desirable. Experiments on small laboratory animals suggest the possibility of using relaxin, which has the profound effect of relaxing the symphisis pubis (1, 2, 4, 5, 7) and may relax the cervical muscle. However, according to Hisaw (6) the animal must be under the influence of the follicular hormone before relaxin can produce symphyseal relaxation. At that time, Hisaw did not know that corpus luteum produced both progesterone and relaxin. Later work by Albert, Money, and Zarrow (3) showed that other parts of the ovary also contain relaxin. Also, Frieden and Hisaw (5) demonstrated some very important physiological actions of relaxin upon connective tissue.