الكاتب: Multiple References

Twenty isolates of Prototheca filamenta, Prototheca moriformis, Prototheca stagnora, Prototheca wickerhamii, and Prototheca zopfii were tested for in vitro susceptibility to five commonly used antifungal agents: amphotericin B, 5- fluorocytosine, griseofulvin, miconazole, and nystatin. The results revealed resistance to griseofulvin of all the Prototheca isolates tested and an inhibitory effect on P. filamenta by high 5-fluorocytosine concentrations (minimal inhibitory concentration [MIC] = 12.5 to 100 ,ug/ml; minimal fungicidal or algacidal concentration [MFC/MAC] = 50 to 100 ,ug/ml). P. filamenta isolates were also susceptible to miconazole (MIC = 0.1 to 0.5 ug/ml, MFC/MAC = 0.5 to 1 ,ug/ml); isolates of the other Prototheca species varied in regard to miconazole activity from susceptible to resistant (MIC = 1 - >100 ug/ml, MFC/MAC = 5 - >100 ,ug/ml). The Prototheca isolates revealed an in vitro susceptibility to the polyene antifungal agents, amphotericin B, and nystatin (MIC = 0.09 to 3.12 ,ug/ml and 0.19 to 12.5 Ag/ml, respectively; MFC/MAC = 0.19 to 25 ,ug/ml and 0.75 to 25 ug/ ml, respectively).