الكاتب: Multiple References

The effect of dynamic antibacterial concentrations on a microorganism in vivo can be studied using a tissue cage model (Kaye et al., 1979; Roos et al., 1985; Beadleet al., 1989; Clarke et al., 1989; Cagni et al., 1995; Xuan et al., 2001). However, the usefulness of this model in pharmacodynamic studies is hampered by the slow rise and decline of concentrations in tissue cage fluid (TCF) of a systemically administered drug. The pharmacokinetic ‘sluggishness’ of the model may be overcome by injection of drug directly into the tissue cage. From a mathematical model elaborated previously it can be deduced that transfer of a drug to and from tissue cages follows first order kinetics and is directly proportional to the ratio of the diffusion area (SA) to the volume (V) of the cage (Bengtsson et al., 1992). Further