الكاتب: Multiple References

Pharmacokinetics of pralidoxime (2-PAM) and its effect on blood enzymes were investigated in male buffalo calves following single intravenous administration (15 mg/kg) . The distribution half-life, elimination half-life, apparent volume of distribution and total body clearance were 0 . 086 ± 0 . 001 h, 2 . 36 ± 0 . 09 h, 1±0-051/kg and 296 ± 13 ml/h/kg, respectively . The drug plasma levels 4 ug/ml were maintained up to 3 h . 2-PAM significantly elevated the serum carboxylesterase and lowered the serum levels of aspartate aminotransferase, alanine aminotransferase, acid phosphatase, alkaline phosphatase and lactate dehydrogenase