الكاتب: Multiple References

Aminoglycoside antibiotics are widely used in veterinary practice because of their activity against many gram‐negative micro‐organisms, including poultry pathogens. The pharmacokinetics (PK) of gentamicin has been investigated in a number of avian species, including male and female chickens (Pedersoli et al., 1990; Itoh & Okada, 1993; Ramsay & Vulliet, 1993). Investigations in turkeys are very limited (Pedersoli et al., 1989). Like other aminoglycosides, gentamicin is a highly polar drug with poor tissue penetration and low values of volume of distribution. The degree of binding to plasma proteins is low (approximately 10%). The absorption is rapid and the absolute bioavailability after i.m. dose is between 70 and 100%.