الكاتب: Multiple References

The single-dose disposition kinetics of difloxacin were determined in clinically normal lactating goats (n ¼ 6) after intravenous (i.v.), subcutaneous (s.c.) and intramuscular (i.m.) administration of 5 mg/kg. Difloxacin concentrations were determined by high performance liquid chromatography with fluorescence detection. The concentration–time data were analysed by compartmental and noncompartmental kinetic methods. Steady-state volume of distribution (Vss) and total body clearance (Cl) of difloxacin after i.v. administration were estimated to be 1.16 ± 0.26 L/kg and 0.32 ± 0.05 L/hÆkg respectively. Following s.c. and i.m. administration difloxacin achieved maximum plasma concentrations of 1.33 ± 0.25 and 1.97 ± 0.40 mg/L at 3.37 ± 0.36 and 1.79 ± 1.14 h respectively. The absolute bioavailabilities after s.c. and i.m. routes were 90.16 ± 11.99% and 106.79 ± 13.95% respectively. Difloxacin penetration from the blood into the milk was extensive and rapid, and the drug was detected for 36 h after i.v. and s.c. dosing, and for 72 h after i.m. administration.