الكاتب: Multiple References
This study compared pharmacokinetic profiles in cattle dosed subcutaneously with two different formulations of enrofloxacin (5% and 10%) at a dose of 5 mg/kg. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by a HPLC/u.v. method. The pharmacokinetic parameters of enrofloxacin and its metabolite were similar in both injectable formulations. Enrofloxacin peak plasma concentration (5%: 0.73±0.32; 10%: 0.60±0.14 μg/mL) was reached at 1.21±0.52 and 1.38±0.52 h to 5 and 10%, respectively. The terminal half-live and area under curve were 2.34±0.46 and 2.59± 0.46 h, and 3.09±0.81 and 2.93±0.58 μg·h/mL, to 5 and 10%, respectively. The AUC/ MIC90 and Cmax/MIC90 ratios for both formulations exceed the proposed threshold values for optimized efficacy and minimized resistance development whilst treating infections or septicaemia caused by P. multocida and E. coli.
تحميل كتاب Pharmacokinetic behaviour of enrofloxacin and its metabolite ciprofloxacin after subcutaneous administration in cattle ، تحميل كتب ، تحميل كتب PDF ، تحميل كتب طب بيطرى PDF ، تحميل روايات PDF ، أحسن موقع تحميل كتب PDF ، أفضل مواقع تحميل كتب
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