الكاتب: Multiple References

fasciolicide agentFasciolosis is an important helminth infection caused by the trematode Fasciola hepatica, a parasite that infests the biliary ducts of many different species (ruminants, horses, humans). This fluke species occurs throughout the world and is a cause of serious economic loss in the animal husbandry industry. A number of drugs have been used in control fasciolosis in animals. Drugs differ in their safety and mode of action. Fasciolicides fall into five main chemical groups: salicylanilides, halogenated phenols, sulfonamides, phenoxyalkanes and benzimidazoles (Fairweather & Boray, 1999). Salicylanilides and halogenated phenols can be regarded as close analogues and include: clioxanide, oxyclosanide, niclosamide, rafoxanide, closantel, nitroxynil, bithionol, hexaclorophene, and niclofolan. With the exception of niclosamide the above-mentioned compounds are usually marketed as flukicides for sheep and cattle, being highly effective against adult and to a lesser extent, immature flukes. Clorsulon, a compound belonging to the sulphonamides family, is also recommended for the control of adult flukes and frequently used in combination with ivermectin. Benzimidazoles have broad-spectrum of activity against a number of nematode, cestode, and trematode parasites (Lacey, 1990).