الكاتب: Multiple References

The pharmacokinetic disposition of enrofloxacin was studied in goats after subcutaneous (S.) Administralion at a single dose of 7. 5 mg / kg body weight Blood samples were drawn from a jugular Vein into heparinized tubes at predetermined timie intervals after administration of the dring and the plasma Was separated by centrifugation. The concentrations of enrolloxacin in the plasma were determined by a microbiological assly using Esc / 1evic / rid coli as the test organism. The plasma concentration - time data were analyzed by non - compartinental methods Enrolloxacin was rapidly | absorbed, an appreciable concentration of the drug (0.30 + 0.13 g / ml) being present in the plasma by5 min after Sc. administration. The maximum plasma concentration of enrofloxacin and the time to reach that maximum Were 2. 91 + 0. 39 Mg / ml and 29 + 0. 51 h, respectively. A detectable concentration of enrofloxacin persisted in the plasma for 12 h. The elinnination half - life and mean residence time of emrofloxacin were 2. 84 + 0. 57 and 5. 74 + 0. 28 h, respectively. It is suggested that enrofloxacin given subcutaneously may be useful in the treatment of susceptible bacterial infections in goats