الكاتب: Multiple References

Adequate parasite control programs are a major contributor to efficient animal production systems. The close relationship between pharmacokinetic behaviour and clinical efficacy for anthelmintic drugs in domestic animals has been demonstrated. Benzimidazole (BZD) and pro-benzimidazole (pro-BZD) are among the most widely used anthelmintic drugs in veterinary and human medicine. These compounds are thought to exert their antiparasite effects by selective binding to parasite tubulin, which produces subsequent disruption of the tubulin-microtubule dynamic equilibrium (Lacey 1990). The use of BZD and pro-BZD compounds quickly became widespread because they offered major advantages over previous available drugs in terms of spectrum, efficacy against immature stages and safety for the host animal (Campbell 1990).