![كتاب Metabolism and residue depletion of albendazole and its metabolites in rainbow trout, tilapia and Atlantic salmon after oral administration](https://www.pdf-books.org/kutubpdfcafe/cover/imagenotfound.webp)
الكاتب: Multiple References
Albendazole (ABZ) is a potent broad-spectrum benzimidazole anthelmintic agent widely used against intestinal helminth infections in mammals (McKellar & Scott, 1990). ABZ is metabolized reversibly to its major active metabolite albendazole sulfoxide (ABZ-SO) by liver microsomal enzymes (Galtier et al., 1986). ABZ-SO is further oxidized irreversibly to an inactive metabolite albendazole sulfone (ABZ-SO2) (Lacey, 1990; Lanusse et al., 1992). The carbamate group of ABZ-SO2 is further deacetylated to form a polar and inactive metabolite, albendazole-2-aminosulfone (ABZ-2-NH2SO2) (Lubega & Prichard, 1991). Figure 1 shows proposed major metabolites of ABZ. ABZ-SO, like parent ABZ, is also marketed as ricobendazole as it has significant anthelmintic activity (Formentini et al., 2001).
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