الكاتب: Multiple References

Paired dam-fetus serum, whole blood and liversamples were collected from 101 pregnant dairy cattle at slaughter to establish mean values for fetal tissue se lenium concentration and to determine relationships be tween maternal and fetal selenium status. Samples were assayed for selenium concentration in serum, whole blood and liver and for whole blood glutathione peroxidase (GSHPx) activity. Fetal age was estimated from fetal crown-torump length. Mean fetal liver(2.14 u.g/g dry wt) and serum (21.4 ng/ml) selenium concentrations and whole blood GSH-Px activity (21.6 ci/ml) differed (P < 0.0001, 0.0001 and 0.01, respectively) from corresponding maternal val ues (0.95 jig/g liver dry wt; 44.0 ng/ml; 16.7 a/ml, re spectively), while no differences were found between whole blood or erythrocyte selenium concentrations. Fetal liver selenium concentration was greater than corresponding maternal liver selenium in 99% (96/97) of the dam-fetal pairs, suggesting efficient placenta! transfer and fetal con centrating ability.Maternal liverselenium concentration was most highly correlated to all fetal tissue selenium concen trations and used to develop prediction models. These data suggest that selenium efficiently passes the placenta, and based on published values of adequate adult liverselenium concentrations and maternal-fetal relationships, we sug gest an adequate liverselenium concentration in the bovine fetus to be > 2.2 u.g/g liver dry wt, and in whole blood, > 120 ng/ml. J. Nutr. 119: 1128-1137, 1989.