الكاتب: Multiple References

Macrolides are considered bacteriostatic at therapeutic concentrations but they can be slowly bactericidal, especially against streptococcal bacteria; their bactericidal action is described as time-dependent. The antimicrobial action of some macrolides is enhanced by a high pH and suppressed by low pH, making them less effective in abscesses, necrotic tissue, or acidic urine.{R-119} Erythromycin is an antibiotic with activity primarily against grampositive bacteria, such as Staphylococcus and Streptococcus species, including many that are resistant to penicillins by means of beta-lactamase production. Erythromycin is also active against mycoplasma and some gram-negative bacteria, including Campylobacter and Pasteurella species.{R-1; 10-12} It has activity against some anaerobes, but Bacteroides fragilis is usually resistant. Some strains of Actinomyces and Chlamydia are inhibited by erythromycin.{R-1; 2} Most Pseudomonas, Escherichia coli, and Klebsiella strains are resistant to erythromycin.{R-2} Cross-resistance to the other macrolides can also occur