الكاتب: Multiple References

The macrocyclic lactones are effective against certain acarines, insects, and nematodes.{R-1} They have no measurable effect on cestodes or trematodes.{R-1} Development of resistance to these anthlemintics by some nematodes in small ruminants and by roundworms in horses has been reported in the United States.{R-47; 49; 100-104} Resistant parasites have been transferred between goats and sheep farmed on the same pasture. {R-100} Animal management and carefully designed anthelmintic protocols are important strategies to limit resistance to macrocyclic lactones. There is cross resistance between the avermectins and milbemycins.