الكاتب: Multiple References

The case was examined at the Easter Bush Veterinary Hospital, The University of Edinburgh. A 520 kg, 6- year-old Thoroughbred gelding was referred for evaluation of acute onset profound depression, head pressing, and lack of response to external stimuli. The horse had a history of moderate weight loss over several months despite adequate nutrition and a good appetite. Previous episodes of weakness had been observed following administration of anthelmintics, namely, alternate doses of pyrantel and ivermectin, administered every 8 weeks. In an attempt to eliminate a possible parasitic cause of weight loss, over the 7 days prior to presentation, the referring veterinary surgeon treated the horse with a 5-day course of fenbendazolea (7.5 mg/kg PO q24h) and moxidectinb (0.4 mg/kg PO), 2 days later. A 5-day course of prednisolonec (1 mg/kg PO q24h) was initiated on the same day as the fenbendazole. This dose was then tapered to 0.5 mg/kg PO q24h, and was still being administered at the time of presentation. On physical examination, the horse was thin, profoundly depressed, unresponsive to external stimuli, and had marked weakness and ataxia. There was bilateral mydriasis and sluggish pupillary light responses. Clinical examination was otherwise unremarkable.