الكاتب: Multiple References

Proteoglycan (PG) release, in response to recombinant human interleukin - 18 (rh-IL-1B), was measured in cartilage explants obtained from the equine distal Sesamoid bone (navicular bone). Fibrocartilage from the surface of the navicular bone apposing the deep digital flexor tendon and hyaline cartilage from the surface of the navicular bone articulating with the middle phalanx were labeled with S04. Hyaline cartilage from the distal metacarpus was used as a control tissue. Following radiolabel incorporation, the three cartilage types were treated with rh-IL-18 (100U / mL) in the presence of hyaluronan (0.2, 2, 20, 200 and 2000 g / mL). rh - IL - 1B - induced PG release was measured by scintillation assay of PG - bound radiolabel. Increases in PG release of 94% (P = .01), 101% (P <.05) and 122% (P <.05).