الكاتب: Multiple References

disposition of fenbendazole in cattle and buffalo. Zurernurional Jourmzlfir Purasilology 2J: 1201-1205. The plasma concentration profiles of fenhendazole (FBZ), FBZ-sulphoxide and FBZ-sulphone were measured following intraruminal adminlstration of FBZ at 7.5 mg kg-’ body weight in cattle and buffalo offered 3 different diets: 100% dry mature sorghum hay, 100% green Peauisefum spp. and a 50: 50 mix of these 2 diets. Changing the diet from dry to green fodder resulted in significantly lower systemic availability of FBZ and its metabolites in both species. Buifalo had a lower systemic availability of the drug than cattle on the dry diet and the difference between species increased when the diet included green fodder. It is suggested that decreased transit time of digesta on the green fodder reduced systemic concentrations by reducing the time available for gastrointestinal absorption of the drug. Key words: anthelmintic; benzimidazole; buffalo; cattle; d