الكاتب: Multiple References

The spectrum of activity of penicillin G includes many aerobic and anaerobic gram-positive organisms. Aerobes susceptible to penicillin G include most beta-hemolytic streptococci, betalactamase-negative staphylococci, Actinomyces species, some Bacillus anthracis, Corynebacterium species, and Erysipelothrix rhusiopathiae. Most species of anaerobes, including Clostridium species, but excluding beta-lactamase-producing Bacteroides species, are also susceptible to penicillin G. Penicillin G is easily inactivated by beta-lactamases and has little efficacy against organisms that can produce these enzymes. In addition, penicillin G is ineffective against those bacteria that are resistant by other mechanisms, such as having a relatively impermeable cell wall. Therefore, penicillin G has little activity against many staphylococci and most gram-negative bacteria