الكاتب: Multiple References

in Beef CattleTelangiectasis is a frequently encountered lesion that leads to economic losses due to the condemnation of the affected parts of the liver in cattle (1-4). These lesions do not lead to any clinical symptoms, they are only come across on post-slaughter examination or during the necropsy process performed on the animals that have died from other causes (1,5,6). They appear grossly as small, red to bluish blood-filled spaces (2,3,5). The following hypotheses have been proposed to explain the pathogenesis of these lesions: focal necrotizing hepatitis (2,3,7,8); metabolic disturbance (1,9); high levels of vitamin A (10); ischemic injury of the hepatocytes from the hepatic portal vein occlusions (11); dilatation of the space of Disse by glycogen extruded from hepatocytes with endothelial rupture and subsequent erosion of the hepatocytes (5,7,8); and reduced density of the reticulin framework with a reduction of the trabecular resistance to the intrasinusoidal pressure (5,12). However, it has recently been suggested that a primary alteration of the sinusoidal barrier as increased deposition of basement membrane components in the perisinusoidal region, and fibrosis are responsible for the development of telangiectasis (8). Furthermore, many investigators have associated telangiectatic lesions and hepatic abscesses (5,13-15).