الكاتب: Multiple References

Anaplasmosis, caused by the rickettsial hemoparasite Anaplasma marginale, is one of the most prevalent tick-transmitted diseases of cattle worldwide (Uilenberg, 1995; Dumler et al., 2001; Kocan et al., 2003). Chlortetracycline and oxytetracycline are, thus far, the only compounds approved for use against acute anaplasmosis in the United States. However, A. marginale infections are not sterilized at the recommended therapeutic doses of tetracycline (Kuttler & Simpson, 1978; Stewart et al., 1979). Furthermore, tetracycline formulations currently marketed for control of anaplasmosis in cattle are not approved for the elimination of persistent infections.