الكاتب: Multiple References

To the Editor—Infections caused by Escherichia coli and other gram-negative bacteria are very common. A large proportion of these strains are resistant to oral antibiotics. When resistance to injectable antibiotics, such as third- and fourthgeneration cephalosporins, is also present, the patient can experience grave consequences, because injectable antibiotics are often the last line of defense and are critically important in treating many lifethreatening infections, including bacteremia and meningitis. Thus, the unexpected and increasing appearance of extended-spectrum b-lactamases (ESBLs) among community isolates of E. coli and other bacteria, as outlined in 2 articles recently published in Clinical Infectious Diseases [1, 2], is of major concern.