الكاتب: Multiple References

Enrofloxacin is a fluoroquinolone antimicrobial agent structu rally related to nalidixic acid and norfloxacin and is licensed for veterinary use only. The fluoroquinolones have a bactericidal spectrum encompassing gram - negative, gram - positive aerobic bacteria and mycoplasma (Reeves et al., 1984: Scheer, 1987a). Enrofloxacin is an important antimicrobial agent that is proving to be very useful in treatment of infectious diseases in many domestic animal species (Scheer, 1987a; Jenkins & Friedlander, 1988; Prescott & Yielding, 1990; Van Landuyt et al., 1990). The primary mechanism of action of the fluoroquinolones appears to be an interaction with the bacterial enzyme DNA gyrase (Vancutsem et al., 1990); Hooper & Wolfson, 1991). This unique mechanism of action differs from that of Blactams, tetracycline, aminoglycosides, macrolides, chloramphenicol and folic acid antagonists and could explain the lack of cross-resistance between these other antimicrobial agents and the fluoroquino-lones (Scheer, 1987a).