الكاتب: Multiple References

Cytochrome P450 monooxygenases (CYP) are involved in the biotransformation of many endogenous and exogenous com --ounds, Inhumans, enzymes from the CYP2C subfamily (predominately CYP2C8 / CYP2C9) are known to play a major role in the metabolism of the hypoglycaemic drug tobutamidel (Relling) et al., 1990); Veronese et al. , 1990; Doecke et al. , 1991; Goldstein & Morais, 1994), as well as in the metabolism of a number of other drugs like phenytoin (Doecke et al., 1991; Veronese et al., 1991), diclofenac (Leemann et al., 1993a) and (S) - Warfarin (Rettie et al., 1992). Furthermore, human CYP2C iso forms are probably involved in the metabolism of several non steroidal anti-inflammatory drugs (NSAIDs) such as tenoxicam piroxicam (Zhao et al., 1992), naproxen (Newlands et al., 1992 Rodrigues et al., 1996). ), ibuprofen (Leemann et al., 1993b) and furbiprolon (Tracy et al., 1995)