الكاتب: Multiple References

It has been shown that netobimin (NTB) is a pro-benzimidazole compound which exerts its anthelmintic activity by cyclization into albendazole (ABZ) metabolites (Delatour et al. 1986). NTB can be formulated either as an insoluble zwitterion or as a water-soluble salt for oral or parenteral administration. Recently, we have investigated the pharmacokinetic behaviour of NTB parent drug and its metabolites in sheep (Lanusse and Prichard 1990) and cattle (Lanusse et al. 1990, 1991). In these studies we have established that both formulation and route of administration may dramatically affect the pharmacokinetic profiles of albendazole sulphoxide (ABZSO) and albendazole sulphone (ABZSO,), the principal metabolites detected in plasma after NTB administration. Furthermore, our results have shown pronounced differences in the disposition kinetics of the above-mentioned metabolites between sheep and cattle.