الكاتب: Multiple References

Comparatively little is known about the ability of commercially raised poultry and gamebirds to metabolize therapeutic drugs as compared with other species. In particular, their ability to metabolize substrates via oxidative pathways, such as those mediated by the family of enzymes known as the cytochrome P450 enzymes, is not as well understood. A need for basic research in this area stems from real-world situations in which poultry are routinely exposed to feed additives and therapeutic drugs, many of which are metabolized via these enzymes. Species differences in drug metabolism affect not only therapeutic efficacy but also drug residues of concern to consumers. The current study was undertaken to obtain an estimation of the putative cytochrome P450 3A (CYP3A) activities in these species using a marker drug.