الكاتب: Multiple References

Ceftiofur sodium, a broad-spectrum cephalosporin, is active against gram-positive and gram-negative pathogens of veterinary importance, including b-lactamase-producing strains, both in vitro and in vivo (Yancey et al., 1987). Like other cephalosporins, ceftiofur isbactericidalinvitro,resultingfrominhibitionofcellwallsynthesis. The drug is approved for treatment of respiratory diseases of cattle, associated with Pasteurella haemolytica (Mannheimia spp), P. multocida and Haemophilus somnus, at doses of 1.1−2.2 mg ceftiofur equivalents (CE)/kg body weight, administered intramuscularly (i.m.) for 3–5 days (FDA, 1988, 1991). Although injection site blemishes rarely occur with i.m. administration, escalating concern in the beef cattle industry over potential blemishes associated with i.m. administration of any product make subcutaneous (s.c.) administration an attractive alternative.