الكاتب: Multiple References

It is well established that the efficacy of any anthelmintic drug depends not only on its affinity for specific parasite target sites but also on its ability to reach high and sustained drug concentrations where the parasites are located. Ivermectin is one of the most useful anti-parasitic agents. It belongs to the family of avermectins that are highly lipophilic macrocyclic lactones. It is a fermentation product of Streptomyces avermitilis. One of the most important characteristics of ivermectin is its wide spectrum of activity involving endo- and ectoparasites. Ivermectin is effective when it is applied orally, parenterally or topically. Its absorption is rapid by any of these routes of administration (Campbell, 1989, 1993). Mange is an ectoparasitic disease produced by the mite Psoroptes ovis. It has major economic importance in South America, especially Argentina, Chile and Uruguay. It is anticipated that in the diseased animal there are kinetic modifications largely dependent on the change of body condition. The objective of the present paper was to determine the pharmacokinetic changes of ivermectin when applied subcutaneously to healthy animals and animals carrying natural mange infections.