الكاتب: Multiple References

In cases of infectious arthritis, there is a localized infection in a body compartment. State-of-the-art treatment consists of local joint lavage and intra-articular administration of antimicrobial agents, often supported by concomitant systemic administration of antimicrobial agents. Although the prognosis for infectious arthritis has greatly improved in recent years, there are still many cases where the infection cannot be controlled, indicating that the quest for improved antimicrobial treatment, locally and/ or systemically needs to continue. A wide range of bacterial species can be found in infected synovial structures. One of the regularly encountered pathogens is Staphylococcus aureus (S. aureus), which belongs to the normal skin flora of both horses and humans (Meijer et al., 2000). In a previous TC study, we investigated whether local administration of ceftiofur was effective in the treatment of S. aureus infection. It was concluded that ceftiofur did not resolve infection in all cases and should therefore only be used with adjunctive therapy. One of the probable causes of this therapeutic failure was the ability of S. aureus to migrate into neutrophils, which was confirmed by microscopical evaluation of cell smears (Bosch et al., 2006).