الكاتب: Multiple References

Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural PolypeptidesLactoferrin is a multifunctional glycoprotein that possesses a variety of physiological roles, such as promotion of iron absorption (26), immunomodulation (16), and inhibiting activity toward different pathogens (14, 16, 24, 26, 32–34), including viruses (1, 2, 7, 9–13, 17–19, 21, 25, 28–30, 38). For all viruses investigated to date, lactoferrin exerts its antiviral activity during the early phases of infection. Recently, we demonstrated a competition between bovine lactoferrin (bLf) and adenovirus for the attachment to cell membrane glycosaminoglycans, even though a binding between lactoferrin and viral particles could not be ruled out (6). The present study provides deeper insight into the mechanism of the antiadenoviral action of bLf, demonstrating that this glycoprotein also exerts its antiadenoviral activity by a direct interaction with adenovirus particles.