الكاتب: Multiple References

Fenbendazole (FBZ) was continuously infused for 30 days into the rumen of 103 lambs which had mature or developing benzimidazole-susceptible or thiabendazole-resistant Haemonchus contortus and susceptible Trichostrongylus colubriformis infections. Ovicidal, larvicidal and adulticidal activities were exhibited against benzimidazole-susceptible and benzimidazole-resistant H. contortus worms by FBZ at a dose level of> 0.2 mg kg- 1 body weight day- 1. Reasonably consistent high level efficacy against H. contortus was obtained with dose levels > 0.4 mg kg- 1 day- 1. Excellent control of susceptible T. colubriformis worms was achieved with the lowest dose tested of 0.4 mg kg- 1 day- 1. The intraruminal infusion critical study method is a tool to determine the feasibility of incorporating a candidate anthelmintic compound in a continuous sustained-release rumen device formulation. The anthelmintic profile of FBZ obtained by low-level intraruminal administration suggests that it would be a potential candidate.