الكاتب: Multiple References

Benzimidazole (BZD) and pro-BZD anthelmintics are widely used in veterinary and human anthelmintic therapy. The use of these compounds became widespread because they offered major advantages over previous available drugs in terms of spectrum, activity against immature parasitic stages and host safety (Campbell, 1990). Ricobendazole (RBZ) or albendazole sulphoxide (ABZSO), is quantitatively the most important active metabolic product recovered in the bloodstream (Prichard et al., 1985; Hennessy et al., 1989) and tissues/¯uids (Lanusse et al., 1993; Alvarez et al., 1999), after administration of either albendazole (ABZ) or its pro-drug (netobimin) in cattle and sheep. Ricobendazole is also available as an anthelmintic compound for use in ruminant species as an oral preparation, and more recently as an injectable formulation for use in cattle (Lanusse et al., 1998)