الكاتب: Multiple References

adrenoceptor agonists have been widely used as - The sedatives, immobilizing agents and analgesics in veterinary medicine for more than two decades. Medetomidine is the most potent and selective of these, and its clinical effects can be reversed by atipamezole, the most selective 02 - adrenoceptor antagonist currently known (Virtanen et al., 1989). This agonist - antagonist combination has been successfully used for reversible immobilization of both domestic and wild animals including ruminants (Jalanka, 1993). Recently. We described the pharmacokinetics and certain clinical effects of medeternidline and alipameole in reindeer and dairy calves (Ranheim et al. 1997: Ranhein et al., 1998). The pharmnacokinetics of nedetomidine have also been determined in sleep (Muge et cl. 1996) and in dogs, cats and rats (Salonen 1989) using tritium labeled drug.