الكاتب: Multiple References

The disposition kinetics, urinary excretion and a dose regimen for ciprofloxacin after a single intravenous administration of 5 mg / kg was investigated in 5 healthy buffalo calves. The disposition kinetics were best fitted to a three - compartment open model. After 1 min, the concentration of ciprofloxacin in plasma was 8. 50 0. 39 + g / ml and the minimum the concentration concentration was maintained for 10h, The elimination half - life and volume of distribution were 3. 88 and 0. 08 h and 3. 97 + 0. 22 L / kg, respectively. The total body clearance and TP ratio Were 0. 709 + 0. 025 L / kg perh and 6. 13 + 0. 54, respectively, Approximately 28. 3% of the total administered dose of ciprofloxacin was recovered in urine within 24 h of administration. To maintain a minimum theatrical plasma concentration of 0. 10 g / ml, a satisficant intravenous dosage regimen of ciprofloxacin, computed on t the basis of disposition kinetic data obtained in healthy buffalo calves, would be 3 mg / kg repeated at 12 h intervals.